Question

Question 8 4 pts Most commercially available microarrays use short-to medium-length oligos as the molecules of choice. True O False 4 pts Question 9 Drug metabolizing enzymes catalyze the Phase I and Phase Il metabolic reactions. True False

Answer 1

8. Answer is : True

Previously cDNA arrays were made by printing oligos onto a glass slide and their length varies between 40 to 100s of base pairs, but now, most commercially available microarrays use short to medium length oligos as molecules of choice with the actual length varying between manufacturers.

9. Answer is : True

Enzymes that catalyze the biotransformation of drugs and xenobiotics are generally referred to as drug‐metabolizing enzymes. The NADPH‐cytochrome P450 reductase (P450R)/cytochrome P450 (P450) electron transfer systems are oxidative enzymes that mediate phase I reactions, whereas the UDP‐glucuronosyltransferases (UGTs) are conjugative enzymes that mediate phase II enzymes.