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Huntington disease is an autosomal dominant condition that doesnt manifests itself until adulthood. Ramon and Julie are marrwith work shown and concepts and formulas explained, please!

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Answer #1

Answer- 1/16

Explanation- As mentioned, the Huntington's disease is dominant as well as autosomal. This means that the diseased person has genotype - HH or Hh. H represents Huntington's allele.

So, if female and male both are heterozygotes, there genotypes will be-

Hh × Hh (Parents)

HH, Hh, Hh, hh (Children)

So, HH, Hh, Hh will be diseased but hh being recessive will be normal. So, probability comes to be 1/4. Let's suppose this is for child aged 5 yrs.

Now, same will be for child aged 7 yrs that is equal to 1/4.

To know the probability of neither of them having the disease, the multiplication rule is used-

1/4 × 1/4 = 1/16.

Hence, 1/16 is the probability.

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