Question

Would a cell with a smaller creatine pool and more mitochondria or greater creatine pool and less mitochondria achieve a cellular steady state quicker?

Answer 1

Creatine is an organic compound and facilitate synthesize of ATP from the ADP in reverse reaction by donating a phosphate group with the help of enzyme creatine kinase. It is manufactured in liver and kidney and work more in the cell which require higher energy level like brain and skeletal muscles.

While mitochondria is present in all cell type and mainly associated with synthesize of ATP by facilitating cellular respiration.

Steady state of cell means maintaining constant concentration of molecule and ions in the cells and organ. Our body uses ATP for various metabolic reactions that’s why keeping ATP above equilibrium level is must, because of ATP decrease the enzyme which uses ATP as substrate will be saturated and reaction rate of metabolic will decrease which mean no steady state of cell.

ATP concentration also kept higher than AMP, lower ATP/AMP ratio trigger AMPK to activate cellular process that return ATP and AMP concentration at steady state. This reaction is processed in each cell of the body except red blood cell where mitochondria is absent. More mitochondria means more energy generation that’s why liver cells are highly regenerative and muscle cells spend high energy in contraction and expansion therefore presence of higher number of mitochondria in liver cells and muscle cells is justified.

By above explanation we can say that to maintain steady state more mitochondria is required while creatine is help in generation of energy for short time like when supplement is given as therapeutic use and in brain or skeletal muscle when required in special situation.