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6. Create a flow chart/concept map showing the relationship between the following for development and activity of the organiz

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Ans 6) I have made concept map showing the relationship between the given proteins for the development and activity of an organizer.

1) Siamois interact with Smad2/4 transcription factor and organizer genes like chordin,noggin and goosecoid are produced. Chordin,noggin and Goosecoid are BMP inhibitors.

2)Organizer can produce Follistatin.Follistatin inhibit BMP. Both BMP and Xwnt8 inhibit Organizer.

3) Cereberus inhibit BMP and Xwnt8 , FrzB inhibit Xwnt8 and nickopf inhibit Xwnt8 which means when BMP and Xwnt8 are inhibited organizer is induced to form nervous system. (Because,BMP inhibit nervous system formation by repressing neurogenin gene. So,these BMP inhibitors are secreted by the organizer to induce ectoderm to form nervous system rather than forming epidermal tissue).

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