Homework Help Question & Answers

Carboxylic acid functional group and Functional amine group

One of the problems with excellent data in vitro is that it is not always guaranteed to be equivalent to data in vivo.  Therefore, it is important that what gives in vitro problems are resolved before getting the drug into in vivo studies to give it a better chance.  

For the following problems, how would you address each of the following for a target in the ER (CFTR)?

1.  If the drug is a small molecule with a carboxylic acid functional group with a pKA of 2.2.

 

2.  If the drug is a base with a functional amine group with a pKA of 8.4.

 

3.  Which of the following drugs above will be more likely to succeed on the target?


0 0
Add a comment
Answer

This Homework Help Question: "Carboxylic acid functional group and Functional amine group" No answers yet.

Be the First!

Request Answer

Request answer!

We need 10 more requests to produce the answer to this homework help question. Share with your friends to get the answer faster!

0 /10 have requested the answer to this homework help question.

Request! (Login Required) Share with friends


Once 10 people have made a request, the answer to this question will be available in 1-2 days.
All students who have requested the answer will be notified once they are available.
Know the answer?
Add Answer to:
Carboxylic acid functional group and Functional amine group
Your Answer:

Post as a guest

Your Name:

What's your source?

Earn Coin

Coins can be redeemed for fabulous gifts.

Similar Homework Help Questions
  • How can we assess whether a project is a success or a failure? This case presents...

    How can we assess whether a project is a success or a failure? This case presents two phases of a large business transformation project involving the implementation of an ERP system with the aim of creating an integrated company. The case illustrates some of the challenges associated with integration. It also presents the obstacles facing companies that undertake projects involving large information technology projects. Bombardier and Its Environment Joseph-Armand Bombardier was 15 years old when he built his first snowmobile...

  • Discussion questions 1. What is the link between internal marketing and service quality in the ai...

    Discussion questions 1. What is the link between internal marketing and service quality in the airline industry? 2. What internal marketing programmes could British Airways put into place to avoid further internal unrest? What potential is there to extend auch programmes to external partners? 3. What challenges may BA face in implementing an internal marketing programme to deliver value to its customers? (1981)ǐn the context ofbank marketing ths theme has bon pururd by other, nashri oriented towards the identification of...

  • Read the Article posted below, then answer the following questions, Please fully answer the following questions...

    Read the Article posted below, then answer the following questions, Please fully answer the following questions about the case. (1000 words all together if possible) (typed no pictures) 1) Perform a PESTEL analysis. This includes discussing the general environment factors affecting the beverage industry’s Performance such as economic, political/legal, socio-cultural, demographic, technological and global issues. 2) Perform Porter’s five forces analysis on the beverage industry. 3) Assess the beverage industry’s attractiveness in terms of growth and profitability. Specifically, present a...

ADVERTISEMENT
Free Homework Help App
Download From Google Play
Scan Your Homework
to Get Instant Free Answers
Need Online Homework Help?
Ask a Question
Get Answers For Free
Most questions answered within 3 hours.
ADVERTISEMENT
ADVERTISEMENT