Give one similarity and one difference between a monomeric G-protein (such as Ras GTPase) involved in...
Give one similarity and one difference between a monomeric G-protein (such as Ras GTPase) involved in enzyme-linked receptor signaling versus the alpha subunit of a heterotrimeric G-protein involved in GPCR signaling.
Homework Answers
Both alpha subunit of a heterotrimeric protein and monomeric G protein (Ras) are required GTP bound form for their function. The alpha subunit of heterotrimeric G protein and monomeric G protein has intrinsic GTPase activity, they can hydrolyze GTP into GDP and convert into GDP bound form or inactive form.
The monomeric G protein differ from the alpha subunit of heterotrimeric G protein, they have a weak GTP hydrolyzing activity, require some other proteins GTPase activating protein (GTP) for GTP hydrolysis whereas alpha subunit can hydrolyze GTP by itself.
Monomeric G proteins also require guanine exchange factor-like sos for their activation which stimulate the release of GDP from Ras and helps in its activation, heterotrimeric G protein alpha subunit does not require any such protein for exchange of GDP into GTP.
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Give one similarity and one difference between a monomeric
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