Which of these are required for full activation of a naive CTL? SELECT ALL THAT APPLY...

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Question

Which of these are required for full activation of a naive CTL? SELECT ALL THAT APPLY...

Which of these are required for full activation of a naive CTL?

SELECT ALL THAT APPLY

	a	IL2 binding to IL2R
	b	CD4 binding to MHC class II
	c	CD28 binding to B7
	d	TCR binding to an Ag/class I MHC complex
	e	CTLA-4 binding to B7

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Answer 1

Answer #1

The full activation of a naive cytotoxic T lymphocytes (CTLs) require

a) IL2 binding to IL2R,

In response to infection, IL-2 important for naive antigen-specific CD8⁺ T cells to proliferate and differentiate into effector cytotoxic T lymphocytes.

b) CD4 binding to MHC class II not required for activation of naive CTLs, but CD8 binds to class I MHC molecule required for its activation.

c) CD28 binding to B7

CTLs activated by co-stimulatory signal mediated by B7 and CD28 present on the surface of antigen-presenting cells (APCs)

d) TCR binding to an Ag/class I MHC complex,

CD8+ T cells (naive CTLs) recognizes antigen presented by MHC class I-derived molecules for their differentiation into effector CTLs.

e) CTLA-4 binding to B7

Activation of naive T cells done by co-stimula-tory signaling system i.e., the interaction of B7 with CTL-associated antigen 4 (CTLA-4)

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Answer 2

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