Question

4. What sequence would best accomplish this transformation? OH - acid (a) [1] SOCl2, [2] (CH3)2NH (b) [1] NH3, [2] excess CHI (c) NaBH4, [2] (CH3)2NH Ta) LiN(CH3)2 - NA

Answer 1

4 0 0-17 12 ใน ปี the conversion is best carried out by the reagents in option 'c' or H asad CH SA - + S sodo Hollole b o a + 50, + L Leit active to react with Now the Chh-e al is too much the secondary amine. OP3 CA Ni els But it we use ". Nitz and 2. Excem CH₂I then, LOAN ion and this undergo no further reaction. for optione, lon Naltia, no reaction an. Na BHq only reduce aldehyder and ketimer. So the en conversion is not posible by optione

for optiond, Lithicomdimethylamine is a strong bose which remove a proton from the carboxylic acid and give Lo + Lid(s), Lou Which cannot give the following product. so, the comersion is not possible by optim d. And the correct answer is a i o 150 ll2 CH3 .IN 2. HNCHE