Question

17. Assign R or S configuration to each chirality center in the following molecule. Draw the two possible chair conformation of the following molecule. Calculate the strain energy of each chair conformation. Identify which conformation is more stable. By how much is it favored? Он CHs Table 1. Steric Strain in Monosubstituted Cyclohexanes 13-Diamial Strain Enagy kCalmol 0.1 0.12 0.25 0.25 Jmol 0.4 0.5 10 1.0 OH 0.50 2.1 COH 0.70 29 CH. 0.90 3.8 CH CH СHICH Сн 0.95 4.0 1.1 4.6 1.5 6.3 СсH 2.7 11.4
can you explain the entire answer please. thank you.

Answer 1

Lower the energy of interaction higher will be stability. The first conformation has Lower energy hence more stable ,

chair conformation OH он With nich 번 Strain energy :- CH₂ at conter → at center ② → R B] Two intraction with OH give 2.1X2 = (4.2 kJ/mot! for @ Two infractions with the gives 31882= 7.6 kJ/mol Greater the strain energy lower will be the Sleebild ty. Hence conformation is more stable than 6 * than

7.6kj/mol - 4.2kj/mol = 3.4kj/mol