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In each reaction box, place the best reagent and conditions from the list below. bupropion (ZybanTM) (used to hel...

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In each reaction box, place the best reagent and conditions from the list below. bupropion (ZybanTM) (used to help people quit smoking)
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Concepts and reason

The concept used to solve this problem is based upon the aromatic electrophilic substitution.

Benzene or substituted benzene undergoes electrophilic substitution reaction on its treatment with an electrophile in the presence of a Lewis acid.

Fundamentals

In an aromatic electrophilic reaction, the substituent or proton present in the aromatic compound is substituted by an electrophile. This reaction occurs in the presence of a Lewis acid which helps in the generation of electrophile.

The various examples of electrophilic aromatic substitution include nitration, halogenation, sulfonation, Friedel craft alkylation, and Friedel craft acylation reactions.

The reactants and products present in the reaction are shown below.

c
bupropion (ZybanTM)

The series of steps involved in the given reaction sequence are shown as:

0.nhub
AICI:
-HCI
CH3
CH2
+
HC
CI
CHZ
propiophenone
Cl2,FeCl3
CH2
phone
Br2, H30+
Br
(CH3)3CNH2
CH
CH3
2-(tert-butylamino)-1-

Ans:

The reagents used in the reaction are given below.

1) CH3CH,COCI, AICI:
2) Cl2, FeCl3
3) Br2,H307
4) (CH3)3CNH2
bupropion (ZybanTM)
C

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