Question

Two reactions between a Grignard reagent and a carbonyl compound are given below. Draw the main organic product for each reaction and indicate if H+ or H- is needed to complete each reaction. (The starting material structures are provided in the answer fields as a starting point for your drawings.)

Two reactions between a Grignard reagent and a carbonyl compound are given below. Draw the main organic product for each reaction and indicate if H+ or H- is needed to complete each reaction. (The starting material structures are provided in the answer fields as a starting point for your drawings.)

Answer 1

Concepts and reason

This problem is based on the concept of reaction of Grignard reagent with carbonyl compounds.

Carbonyl compounds (aldehydes and ketones) are extremely reactive towards the nucleophile due to their highly electrophilic nature. Carbonyl groups include a carbon which is attached to the oxygen atom which highly electronegative as compared to the carbon and hence attracts the shared pair of electrons which results in the generation of partial positive character on the carbonyl carbon.

Fundamentals

Grignard reagents on reaction with carbonyl compounds carry out a nucleophilic addition reaction which on treatment with water gives a corresponding alcohol.

(1)

The reaction of Grignard reagent with the ketone is given below:

(2)

The reaction of Grignard reagent with the aldehyde is given below:

Ans:

The organic product of the reaction is

.