Question

Draw the major organic product of the following reaction. Draw the major organic product of the following reaction...

Draw the major organic product of the following reaction.

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Draw the major organic product of the following reaction.Draw the major organic product of the following reaction.
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Answer #1
Concept and reason

The concept used to solve this question is formation of an alcohol by the reaction between epoxide and Grignard reagent.

Grignard reagent acts as a nucleophile, attacks the electrophilic carbon after the ring opening to form an intermediate metal alkoxide salt. Acidic work up converts the metal alkoxide salt into an alcohol.

Fundamentals

The substituents on the epoxide will decide the alcohol formed in the reaction. The ring opening of the epoxide occurs from the less substituted side and the attack of the nucleophile occurs on the same side.

The general formula of a Grignard reagent is RMgX{\rm{RMgX}} , in which R is an alkyl group, Mg{\rm{Mg}} is a metal, and X is a halogen. The alkyl group acts as a nucleophile.

Reaction of epoxides with a Grignard reagent followed by the hydrolysis forms an alcohol (new CO{\rm{C}} - {\rm{O}} bond in the product).

1.

The reaction between epoxide with Grignard reagent yields an alcohol.

CH2CH3
CH2CH3
CH3CH MgBr
MgBrt
HO

The reaction between epoxide with Grignard reagent yields an alcohol.

CH3CH MgBr
LÓ MgBrt
H3CH2C
ht
OH
→ H3CH2C

Ans: Part 1

The reaction is as follows:

OH
Å
can changes , nange You
CH3CH MgBr
H3CH2C
H+

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