Question

Sulfonamides act by _____ inhibition of ______ by mimicking the native substrate of the enzyme, _______...

Sulfonamides act by _____ inhibition of ______ by mimicking the native substrate of the enzyme, _______

choices for all three blanks:

tetrahydrofolate

dihydropteroate synthetase

reversible

irreversible

dihydrofolate reductase

transpeptidase

p-aminobenzenesulfonic acid

glutamic acide

p-aminobenzoic acid

p-nitrobenzoic acid

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Answer #1

Solution:

  • Sulfonamides act by irreversible inhibition of dihydropteroate synthetase by mimicking the native substrate of the enzyme dihydrofolate reductase.
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