1. What is a Coombs Check cell and what do Coombs Check cells control for? 2.Provide...
1. What is a Coombs Check cell and what do Coombs Check cells control for?
2.Provide two examples of times in the blood bank laboratory you might want to complete Rh phenotyping?
3. Explain the phenomenon of dosage by creating two different sets of Rh phenotype results and discussing how cells with those phenotypes could be used to show dosage.
Homework Answers
Coombs check or control cells are nothis but antibody coated RBCs with IgG antibody. Freshly isolated RBCs are incubated with IgG and then washed followed by preservation with antibiotics. Shelf like is approximately 4 weeks.
Coombs cells are used to detect autoimmune induced hemolytic anemia. in tis case antibodies are against its own body RBCs. if the coombs test is positive indicates autoimmune disease.
Also coombs test is done before transfusion.
It is of 2 types direct & indirect test. Application includes mycoplasmic infection, infevtion mononucleosis, chronic leukaemic leukemia etc
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1. What is a Coombs Check cell and what do Coombs Check cells
control for?
2.Provide...
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answer question #2 a-f
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answer question #2 a-f
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Human blood types A, B and O are associated with the carbohydrate antigens A, B and H respectively. A and B antigens are caused by an alteration of H antigen. Normally everyone can synthesize H antigen (a cell surface carbohydrate found on red blood cells and other cell types). Some people make A and/or B transferase(s) which converts the H antigen to an A and/or B antigen respectively. The H antigen is produced by a specific fucosyltransferase encoded by the...
immunology
practing samples and not sure if my answers correct.
1. NK cells are effective against viral infections because many virus infected cells a. are susceptible to lysis b. are susceptible to phagocytosis c. show reduced levels of MHC class I molecules d. show reduced levels of MHC class II molecules e. none of the above 2. Arachidonic acid serves as a substrate in the lipoxygenase and cyclooxygenase pathways resulting in the production of a. histamine, leukotrienes b. leukotrienes, prostaglandins...
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