Question

X Incorrect. Follow the steps given in the hint. Reserpine can be isolated from the extracts of the Indian snakeroot Rauwolfia serpentina and has been used in the effective treatment of mental disorders. R. B. Woodward employed the following reaction sequence in his classic 1958 synthesis of reserpine (Tetrahedron 1958, 2, 1-57). After compound 1 was prepared, it was treated with molecular bromine, followed by sodium methoxide, to afford compound 2, which rapidly undergoes a Michael reaction to give compound 3. ОН Hmo 1) Bra 2) NaOme OMS Draw curved arrows to depict a probable mechanism for the conversion of compound 1 to the short-lived intermediate 2 with respective charges. Include lone pairs in your answer.
Could you please let me know the steps of this problem?

Answer 1

CHAPTER => Mechanis m И () H и h -Nasr Paiod Readas I meoH O s of the ls eentaim Моа а bials ore bbreviate In birst Step sr, moleeule atcule ou denuale bond which b lrem ler inderd spaue. in tis step dH uncton Gp nmeleule unde go inka molewar attask o husm ac-o-c bond T er in Hai's step metaxy anlone abshaut Hae autve ohydrogen ho eliminate methanol auwel | Tig 15 (al In Fig. 1.8 (al bech orbitals.are net mirror imnges to ench ather. Thos in this MD thers -ed p arbit в вдегу orbilals cated wth ntibonding is mirrer s ane aametrs, abbewiated as mCAl. The centre of 8ymmetry is a paint in the maiccular aria frum which if lines are drawn on ane side and extendnd an qual distanon on the other sile, will met the me phass ot the arbitaie Ple L8 (A I of increas has ser Centre af the molenular asia CU Nasr 4 olm bonble bond. et te the Fig. 1. 4 he s syetem ntrw of the r Deth arbitaie in Fie 18 () are smetrical with rispert to eentr of he malenular ads. Thes in lsis MO thee in cntre of aymmetry, whbreviated as CS