
Determine, based on the identity of the substrate, nucleophile, and solvent, the mechanism of nucleophilic substitution...
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Determine, based on the identity of the substrate, nucleophile and solvent, the mechanism of nucleophilic substitution of each reaction and draw the products, including stereochemistry. DMF OTs Y Steps nistry Steps Chemistry Steps 1) Chemistry t OHmby Ste 2) Chemistry Steps MECN н.с-о — 3) + Br istry Steps Chemistry Steps Chemistry Steps Chemistry Steps
1. Determine the mechanism of each nucleophilic substitution reaction and explain why? Draw the products including the stereochemistry. (6 points) Br + CN acetone d. ~ + CH,CO2H - Y Y + POCHE UCH DMSO + TOCH.CH DMF b. + B + OCH + CH4OH DMSO – w ! ho + OCHCH , CH,CH,OH DM . Br + CH3OH + CH3CH,OH
4. Considering the structure of the substrate, the nature of the nucleophile, and the solvent (written on the arrows), determine the type of mechanism (Snl or S2) for every reaction. Predict the products and draw the mechanism DMF + KN3 ОН + water H-CI а) b) ethanol Br acetone CH3CH20H KI Br d) Br DMSO DMSO Br + КCN KSCH2CH3
4. Considering the structure of the substrate, the nature of the nucleophile, and the solvent (written on the arrows), determine the type of mechanism (Sxl or Sx2) for every reaction. Predict the products and draw the mechanism. + KN. DMF a) (KN=N=N) 6 YOH + H-al water ethanol + CH3CH OH acetone Br + KI Br Br + DMSO DMSO CCB + KCN KSCH2CH3 D er + ken DMSO
3. Determine the mechanism of nucleophilic substitution (SNI or SN2) for each reaction and draw the products. Be aware of stereochemistry. 8 + CN - dletone m et och cun, DE Br + OCH₂ CH₂ DME 4. Draw all constitutional isomers formed during each elimination reaction after determining whether it is E1 or E2. habel it as El or E2. госна. a y "ocha, B b. Tă CH₃OH Br -OH
1.) Determine the mechanism. (Sn1 or Sn2)
2.) Show step by step reaction mechanism of nucleophilic
substitution including transition states
3.) Draw the products, including stereochemistry
Br + CN acetone
Based on nucleophile, substrate, and reaction conditions, state the most likely reaction mechanism (s_n 1 or s_n 2) in each example. Draw the products, including stereochemistry as needed. Predict the product of the following reactions:
Draw the mechanism for Nucleophilic Acyl Substitution of an acid
chloride and a nucleophile (Nu:-). Be
sure to draw all starting materials, products, intermediate, and
curved arrows necessary to describe this mechanism.
Draw the two products for the following reaction: H30+ N
6. Determine the mechanism of nucleophilic substitution for each reaction and indicate the stereochemistry of the products. (in WORDS - DON'T DRAW DRAW PRODUCT BUT NOT Stereochemistry A. Br Brt + CN-acetons B. Br or n + CH₃OH Hochz - + OCHCH DME> c. 7. Label each stereogenic center as Rors A. a c. HO B ...oh OH NH 8. How is each compound related to the first compound D-erythrose (A+B) Oh. HK CH OH 04 I CH -04 D-erythrose...
2. Predict the product(s) of each of the reaction conditions
below. Specify the substrate type (primary, secondary, or tertiary
alkyl halide), nucleophile (strong or poor), and the solvent type
(protic or aptrotic). Specify the type of reaction mechanism (SN1
or SN2), show the curved arrow mechanism and draw the products as
3D structures to illustrate stereochemistry.
Predict the product(s) of each of the reaction conditions below. Specify the substrate type (1º, 2º, or 3 alkyl halide). mucleophile (strong or poor),...