Creatinine clearance test:
Creatinine is a waste product from the normal breakdown of muscle tissue.As creatinine is producted its filtered through the kidney and excreted in the urine.Based on the creatinine level the kidneys function is evaluated.
The amount of blood the kidneys can make creatinine free is called the creatinine clearance.Creatinine clearance in an healthy person is about 95milliliters per minute(women) and 120milliliters per minute(men) which means each minute that persons kidney clears 95-120ml of blood free of creatinine.
The GFR can vary depending on age,sex and gender.
Measuring Creatinine Clearance and Renal Function.
There are two ways if measuring the creatinine clearance level
For practical reason Blood estimation is done more than the urine test.
An outpatient who is pregnant collected a urine sample for creatinine clearance as her physician ordered. But, she collected twenty hours because she thinks it would not matter if the collection time is different. She provided her height and weight (5’7” and 100 kilograms). The lab assistant, who received her urine, measured the total volume and reported as 3,500 ml, made an aliquot then she discarded the rest of the urine. The blood was centrifuged and was sent to chemistry...
The physician ordered a creatinine clearance for an inpatient that possibly has early onset of renal problems. The nurse was instructed to collect 24 hours of urine sample with a total volume of 950 ml. The plasma creatinine was analyzed from the specimen during the early morning draw along with Complete Metabolic Panel. The result was 3.5 mg/dL. The urine chemistry result was 185 mg/dl. Calculate the creatinine clearance in ml/min.
Calculate the Creatinine Clearance for a 25 year old male that weighs 169.4 lbs, is 5ft 10in in height and has a serum creatinine (SCr) level of 0.8 mg/dL.
Using the Cockcroft-Gault Method, what is the estimated creatinine clearance for 49 year old male patient who weights 154 pounds and has serum creatinine of 0.8 mg/dl? A 103 ml/min B 114 ml/min C 94 ml/min D 110 ml/min
Using the Cockcroft-Gault Method, what is the estimated creatinine clearance for a 49-year-old male patient who weighs 154 pounds and has a serum creatinine of 0.8 mg/dL? a 110 mL/min b 94 mL/min c 114 mL/min d 103 mL/min
Patient #1 is a 35yo male who brought in a urine jug for a 24hr creatinine clearance. The volume of the urine was 1000mL. The patient’s height is 6ft and he weighs 230lbs, with an approximate body surface area of 2.24. Creatinine Clearance Results: Range Serum Creatinine: 0.8mg/dL (0.6-1.2) mg/dL Urine Creatinine: 66.2mg/dL Clearance Rate: (85-125) mL/min Determine the Clearance Rate. What is the discrepancy in these results? Name at least 3 possible reasons for this discrepancy:
(3 pts) Quantitative characterization of renal clearance, use words to describe equation 16: (16)
(3 pts) Quantitative characterization of renal clearance, use words to describe equation 16: (16)
What mechanisms are involved in clearance? Describe them and illustrate the process by which a deleterious mutation—say, the allele Abad—is cleared. Why doesn’t clearance typically occur in asexual species? Say two deleterious alleles, Abad andBbadder , are fairly close to one another on the same chromosome. Describe/illustrate how only one of the two deleterious alleles are transmitted to the next generation as opposed to both of them
Describe in your own words what glomerular filtration rate (GFR), blood urea nitrogen (BUN) and creatinine are and what they indicate in patients. Why should health care professionals analyze both BUN and creatinine to determine renal disease?
8) Cancer immunoediting. Describe two changes a cancer cell undergoes to evade immune detection and clearance. For each change describe how immunologically this leads to evasion of the immune response. 2-3 sentences for each response. (4 pts)