Question

1. You are caring for a child with acute lymphoblastic leukemia. She has been genotyped and is homozygous for a TPMT polymorphism, producing very little of the enzyme needed for this drug's metabolism. How would you expect this to affect dosing of the drug 6-mercaptopurine?

   	a.	This child should receive the standard dose.
   	b.	This child should receive higher doses than the standard dose.
   	c.	This child should receive only a small fraction of the standard dose.
   	d.	This child should receive the drug intravenously rather than orally.

Answer 1

ANSWER.

* Thiopurines are used for the treatment of acute lymphoblastic leukemia.

* Child with acute lymphoblastic leukemia producing very little of the enzyme

   needed for thiopurine s -methytransferase metabolism.

C) So this child should receive only a small fraction of the standard dose.