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Sophia OConnor was a 56 year old attorney in 2011, when she began to experience excessive fatigue. She had been in good heal
In April of 2016, further chemotherapy was given because of the persisting elevation of her serum IgG. She was treated for 9
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1, Multiple myeloma:
It is cancer formed by malignant plasma cells. this patient diagnosed with this disease due to a patient biopsy report shows plasma cyloma and bone marrow revealed predominant accumulation of plasma cells(a form of WBC). plasma cells become cancerous and multiples, it damages the bone, immune system, and RBC count. patient anemic condition and high IgG level cause multiple organ damage and patient experience with various symptoms indicate the patient is having multiple myeloma. presence of Bence-jones protein int the urine indicates the immunoglobulin light chain in the urine causes multiple myeloma.
2, Myeloma cells disturb the blood cells form in the bone marrow. so there is less RBC or anemia. There are multiple formations of plasma cells in the bone marrow that interfere with the normal blood-forming cells that cause low WBC.
3, Pyogenic infection is pus producing infection with strains of staphylococcus aureus that cause pneumonia and renal dysfunction. this happens mainly due to the humoral immunity defect or functional impairment of natural killer cells and polyclonal hypogammaglobulinemia.
4, Antibody play an important role in acting against particular microorganism. IgG autoantibodies react with human molecules contribute to the pathogenesis. Streptococcus are gram-positive, that occur in pairs or chains. emergence of S pyrogens resistant to penicillin and other antibiotics, it becomes a microbial threat. S pyogenes are part of normal human nasopharyngeal flora, that cause inflammation in the respiratory tract, bones, and joints. S.pyogenic recurrence is common, life long antibiotics prophylaxis is recommended. Antibiotic resistance must be treated with these common pathogens.

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