Question

In Multi organ dysfunction syndrome what is the oxygen supply and demand imbalance

Answer 1

Multiorgan dysfunction syndrome involve failure of more than two organs like liver, lung, kidney, spleen ..it happens as a result of activation of several endogenous metabolic pathways..This is usually cytoprotective over exuberant activation of this system results inflammation response leads to organ failure..

Dysfunctional immune system response for sick patient homeostasis can not be maintained..There will be metabolic molecular physiology increased oxygen demand and inadequate oxygen supply.. Exaggerated inflammation induces collateral tissue damage and necrosis of cells to die..iinflammation due to lipopolysaccharide components made linked with bacterial sepsis and it's plasma concentration is linked with oxygen dysfunction..There is microcirculatory hemostasis and reduction in capillary density, perfusion and it will affect the vascular system..

Perfusion results less functional activity and microcirculation hypoxic and less oxygen extraction capacity made cytopathic hypoxia which impact on mitochondrial behaviour..