
17. Propose starting materials needed to synthesize each molecule through a Claisen reaction. a. Eto =...
17. Propose starting materials needed to synthesize each molecule through a Claisen reaction. a. Etor = = COMe = d. EO Y OEt f Ph TY = =
10. Propose starting materials needed to synthesize each molecule through an aldol reaction. a. b. c. d. H f. 11. Give the curved arrow mechanism for each Claisen reaction. a. NaOEt a. b. mild H EtO EtO 1 11 continued a. NaOMe MeO b. b. mild H МеO a. NaOEt с. b. mild H
16. Give the major organic product of each Claisen reaction. a. NOF: A WHO it heat b. H.H.O. ETO a. NaoMe b. H. H,0,hea MCO- a. NaOE. a. NaOme. O Mco CCH) OMe b. H.H.O, heat 17. Propose starting materials needed to synthesize each molecule through a Claisen reaction. a. F10 1 1 1 d. EOYOE 1 Ph YYY = 1
10. Propose starting materials needed to synthesize each molecule through an aldol reaction. من . . ) » سالب = ، د سال دیگر = = مر
23.8 Propose the two ester starting materials for the crossed Claisen product shown below. a time love (b) th ОMe in the name + gome (d) OMe thom have 23.8 Propose the two ester starting materials for the crossed Claisen product shown below. NaOME them
7. Show the starting materials, conditions, and steps to make each compound via Claisen reaction or Dieckmann cyclization: b OO OME OEt
12. Explain why a Claisen reaction occurs with ester E, but not with ester F. Eto EIO E F 13. Give the major organic product of each Claisen reaction. In some cases, no reaction is expected. a. NaOEt a. NaoMe OMe b. mild H Et01 b. mild H a. NaOMe a. NaOme. Meo MeO b. mild H MeO b. mild Hº 13 continued a. NaOE AOE a. NaOE, O Eto OE OE OEt c. mild H b. mild H a....
6) Provide the structures of the starting materials needed to synthesize the molecule below 7) Out of the two starting material identified in question 6 above, which one forms the enolate?
8. Give products or required starting materials for these crossed-Claisen condensations that use two different esters. Note that the first ester is added to the base to form an enolate. (If the base were added to the ester, enolates would form and react with the ester present in the flask). Give the enolate for the first reaction. 1) O 2) OK iPro ОMe Meo t-butoxide THF 1) 2) N LÝ OMe Eto Meo LDA 1) 2) Meo Оме Eto LDA...
Give the major organic product of each reaction. 8. a. LDA н b. H c. mild H NaOH, H,O н a, LDA b. f. н NaOH, H,O, heat c. mild H NaOH, H,O O NaOH, H,O H CYD a. LDA b. d. h. NaOH, H,O, heat c. mild H*, heat 9. Give the major organic product of each intramolecular Aldol reaction. NaOH, H,O a. heat H NaOH, H2O b. heat NaOH, H,O NaOH, H20 d. heat 10. Propose starting materials...