Question

Consider the following reaction: 2. 1. NaOMe/MeOH 2. H,о" Does it have a specific name? How many products are possible? Show all of them Suggest a synthetic route that leads to a lesser number of products.

Answer 1

Answer:

Oplar, y han egen har 1. NaOM/MeOH OMe + en Y HOME H 2. H300 a)Its a Claisen Condensation reaction Co Y NaOM/MeOH OMe YooMe enolate доме carbanion Meow There are two possible reactions Cross Claisen Condensation reaction: Me o oby how man of the love OMe MeOH oMe Me carbanion Self Claisen reaction 0 0 0 0 HO // V OM O OMe Med Me -MeOH ON carbanion c) To minimize the product from self Claisen condensation reaction the rection procedure to be foolowed is We need to take an ester methyl benzoate (not capable of self reaction) is taken with NaOme/MeOH in reaction flask and then very gradually in dropwise fashion an other ester methyl propionate, As methyl propionate ester which is capable of self Claisen reaction encounters other ester methyl benzoate which is more reactive the cross Claisen reaction occure almost exclusively and only cross Claisen Condensation product forms.

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