Question

The following plots shows two different scenarios for the decline of plasma concentration foll owing the administration of an iv-bolus. Which of the two profiles represent a situation in which elimination is much faster than distribution? 00.0A 100.0 10.0 10.0 1.0 1.0 0.1 48 72 0.1 72 Hours None O B Both

Answer 1

answer ....B.

B profile show is a elimination more than distribution

distribution phase ....during the distribution phase , change in concentration of drug in plasma reflect primarily movement of drug within body

ELIMINATION PHASE ..is a late phase .once the drug in the plasma and tissue has reached equilibrium, decline of plasma concentration is driven by elimination of drug from the body.