Question

20. In human the oral hypoglycemic agent acetohexamide (Dymelor) is metabolized to trans-4 hydroxcyclohexyl product. Draw the most stable conformation of the metabolite. ం Acetohexamide (Dymelor) 21. Two human urinary metabolites of phenycyclidine (PCP) have been identified as the 4-hydroxypiperidyl and 4-hydroxycyclohecyl derivative of the parent compound. Draw the most stable conformation of each metabolite. Phenycyclidine 22. Myo-Inositol, one of the isomers of 1,2,3,4,5,6-hexahydroxycyclohexane, acts as a growth factor in both animals and microorganisms. Draw the most stable chair conformation of myo-inositol. Calculate the amount of steric energy in the most stable conformation of myo-inositol if 1,3-diaxial interaction of hydroxyl group with a single hydrogen is 2.1 KJ/mol. он но. OH но° "Он Он Myo-inositol

Answer 1

Lon forma Nost Stable 20 NH keep bulky rup Reusons befns to bosihion A b tabilis u membued Hy drogen eguitomal at 6truuu. the bonded metwork OS12

oavoid Reasons Sterue dash wi 21 Totons, it haul euy bungene bosihon egui to mal

92 .OH H 14 un stasle most mOst mos Stawle mos as axial OH at Ore posinon sui to ma bosikon hus 4 mOs form in unstusle 1 daa xi al interahon (marked KJ mol- enerag 2X21 4-2 KSmol- Henu, stune most &tote orm: in energy