Question

ethers and epoxides can both undergo acid-catalyzed or base-catalyzed substitution reactions. Pimobendan (shown below) is a cardiac drug used to treat dogs with congestive heart failure.

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Pimobendan is taken orally, so it has the potential to react with stomach acid (HCl). Using your knowledge of ether reactions, predict if the ether functional group in Pimobendan is likely to react in a dog's stomach. If you think no reaction will occur, explain. If you think a reaction will occur, describe the mechanism and predict the product.

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Answer #1

CH3 —ОН H+ CI- HNN HN CH CEO O CH CH3-CI There is a methoxy ether present in the Pimobendan molecule. The ether oxygen is fir

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ethers and epoxides can both undergo acid-catalyzed or base-catalyzed substitution reactions. Pimobendan (shown below) is a...
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