Based on the reaction ( salicylic acid reacted with R-(+)-a-Methylbenzylamine) and EDCl, with Catalyst DMAP and...
Based on the reaction ( salicylic acid reacted with R-(+)-a-Methylbenzylamine) and EDCl, with Catalyst DMAP and DMF) and basic condition, list at least two other products that may be formed in addition to the desired product.
Homework Answers
![NH2 O CH EDCI, DMAP, DMF basic condition -CH₃ NRY он 2-hydroxy-N-[(1R)-1-phenylethyl]benzamide This is the expected product.](http://img.homeworklib.com/questions/5ae5e660-77f3-11ea-8d5f-87441ed23cbd.png?x-oss-process=image/resize,w_560)
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Based on the reaction ( salicylic acid reacted with
R-(+)-a-Methylbenzylamine) and EDCl, with Catalyst DMAP and...
1.) Please help me to figure out if this is the correct product, and if you...
1.) Please help me to figure out if this is the correct product,
and if you could also give me an arrow pushing mechanism.
(Salicylic Acid + Benzylamine reacting with EDCI, Cat. DMAP and
DMF).
2.) What is the purpose of adding EDCI as a coupling
reagent?
3.) Which groups in this reaction can undergo any type of
covalent and/or non covalent interaction with any enzymes or
receptors?
4.) What are at least two other side products other than the...
List and justify an alternative method to synthesize your target molecule that might increase the overall efficiency of...
List and justify an alternative method to synthesize your target molecule that might increase the overall efficiency of your synthesis (like higher yields of the desired target and reduction of the side products formed). The reaction is about the carboxylic acid react with primary amine to get amide product by using EDCl and Catalyst of DMAP and DMF.
Calculate theoretical and percent yield. In this experiment, salicylic acid and acetic anhydride will be reacted...
Calculate theoretical and percent yield. In this experiment, salicylic acid and acetic anhydride will be reacted to form acetylsalicylic acid in an acid catalyzed reaction. In a reaction tube, add approx. 140 mg salicylic acid, a boiling chip and a small drop of 85% phosphoric acid. Add 0.3mL acetic anhydride, which should wash the reactants to the bottom of the tube. Mix thoroughly. Heat in a beaker of water at 90oC for 5 min. Cautiously add 0.2 mL water to...
In the mechanism for formation of acetylsalicylic acid via reaction of salicylic acid with acetic anhydride,...
In the mechanism for formation of acetylsalicylic acid via reaction of salicylic acid with acetic anhydride, phosphoric acid acts as a catalyst by O cleaving an acetyl group from acetic anhydride via protonation of the bridging oxygen O neutralizing the hydroxide ion side product protonating the carbonyl oxygen in the acetic anhydride protonating the phenolic oxygen of salicylic acid Question 10 (3 points) What would be the predicted major product from the thermodynamically controlled dehydration of the following material OH
use condensed structural formulas to write the balance equation for the reaction of salicylic acid with...
use condensed structural formulas to write the balance
equation for the reaction of salicylic acid with acetic
anhydride.
Use the models to demonstrate the reaction
use condensed structural formulas to write the balance
equation for the reaction of salicylic acid with methanol.
Use the models to demonstrate the reaction
Describe the appearance of aspirin product
REPORT SHEET: ASPIRIN Name Partner(s) Date Section Instructor A. Molecular models Use condensed Ne condensed structural formulas to write the balanced equation for the reaction...
Acid Catalyzed Hydration-treatment of alkenes with water in the presence of acid catalyst leads to the...
Acid Catalyzed Hydration-treatment of alkenes with water in the presence of acid catalyst leads to the formation of alcohols. H2SO4/H2O > 150°C Mechanism Major Product Acid catalyzed dehydration goes through a carbocation intermediate. This means that the Markovnikov product is obtained when carbocation rearrangements do not occur. The need for excessively high temperatures makes this reaction of limited use in laboratory synthesis. Oxymercuration - Oxymercuration involves the addition of Hg to the alkene using mercury (II) acetate Hg(OAc) followed by...
1.The acetylation of salicylic acid may form a mixed anhydride as temporary side product. Typically, this...
1.The acetylation of salicylic acid may form a mixed anhydride
as temporary side product. Typically, this compound rearranges to
acetylsalicylic acid (aspirin). Provide a mechanism for this
reaction.
2. Which of the following two compounds do you expect to be a
stronger acid? Explain your answer.
8 Aspirin Lab Spring 2019(1) Word FILE HOME INSERT DESIGN PAGE LAYOUT REFERENCES MAILINGS REVIEW VIEW Sign in 5. The acetylation of salicylic acid may form a mixed anhydride as temporary side produet. Typically,...
Attempts to isolate the product of this reaction yielded solid salicylic acid, rather than liquid wintergreen...
Attempts to isolate the product of this reaction yielded
solid salicylic acid, rather than liquid wintergreen (methyl
salicylate.) Why?
НО. H2SO4 catalyst microwave HEC OH OH + H2C-OH 30% power 75 seconds methanol salicyclic acid methyl salicylate "wintergreen"
What is the role of acid catalyst in this reaction? And list any precautions when using...
What is the role of acid catalyst in this reaction? And list any
precautions when using acetic anhydride.
one o ОН ld woman to create H3 SO4 OH + CH2COOH OH 0-C-CH3 Salicylic Acid MM 138.12 g/mol Acetic Anhydride MM 102.09 g/mol d 1.08 g/mL Acetylsalicylic Acid MM 180.16 g/mol Acetic Acid MM 60.05 g/mol
Draw the product of the reaction of salicylic acid with (a) one of NaOH. (b) two...
Draw the product of the reaction of salicylic acid with (a) one of NaOH. (b) two equivalents of NaOH, and (c) two equivalents of NaHCO_3.
1.) Please help me to figure out if this is the correct product,
and if you could also give me an arrow pushing mechanism.
(Salicylic Acid + Benzylamine reacting with EDCI, Cat. DMAP and
DMF).
2.) What is the purpose of adding EDCI as a coupling
reagent?
3.) Which groups in this reaction can undergo any type of
covalent and/or non covalent interaction with any enzymes or
receptors?
4.) What are at least two other side products other than the...
In the mechanism for formation of acetylsalicylic acid via reaction of salicylic acid with acetic anhydride, phosphoric acid acts as a catalyst by O cleaving an acetyl group from acetic anhydride via protonation of the bridging oxygen O neutralizing the hydroxide ion side product protonating the carbonyl oxygen in the acetic anhydride protonating the phenolic oxygen of salicylic acid Question 10 (3 points) What would be the predicted major product from the thermodynamically controlled dehydration of the following material OH
use condensed structural formulas to write the balance
equation for the reaction of salicylic acid with acetic
anhydride.
Use the models to demonstrate the reaction
use condensed structural formulas to write the balance
equation for the reaction of salicylic acid with methanol.
Use the models to demonstrate the reaction
Describe the appearance of aspirin product
REPORT SHEET: ASPIRIN Name Partner(s) Date Section Instructor A. Molecular models Use condensed Ne condensed structural formulas to write the balanced equation for the reaction...
Acid Catalyzed Hydration-treatment of alkenes with water in the presence of acid catalyst leads to the formation of alcohols. H2SO4/H2O > 150°C Mechanism Major Product Acid catalyzed dehydration goes through a carbocation intermediate. This means that the Markovnikov product is obtained when carbocation rearrangements do not occur. The need for excessively high temperatures makes this reaction of limited use in laboratory synthesis. Oxymercuration - Oxymercuration involves the addition of Hg to the alkene using mercury (II) acetate Hg(OAc) followed by...
1.The acetylation of salicylic acid may form a mixed anhydride
as temporary side product. Typically, this compound rearranges to
acetylsalicylic acid (aspirin). Provide a mechanism for this
reaction.
2. Which of the following two compounds do you expect to be a
stronger acid? Explain your answer.
8 Aspirin Lab Spring 2019(1) Word FILE HOME INSERT DESIGN PAGE LAYOUT REFERENCES MAILINGS REVIEW VIEW Sign in 5. The acetylation of salicylic acid may form a mixed anhydride as temporary side produet. Typically,...
Attempts to isolate the product of this reaction yielded
solid salicylic acid, rather than liquid wintergreen (methyl
salicylate.) Why?
НО. H2SO4 catalyst microwave HEC OH OH + H2C-OH 30% power 75 seconds methanol salicyclic acid methyl salicylate "wintergreen"
What is the role of acid catalyst in this reaction? And list any
precautions when using acetic anhydride.
one o ОН ld woman to create H3 SO4 OH + CH2COOH OH 0-C-CH3 Salicylic Acid MM 138.12 g/mol Acetic Anhydride MM 102.09 g/mol d 1.08 g/mL Acetylsalicylic Acid MM 180.16 g/mol Acetic Acid MM 60.05 g/mol
Draw the product of the reaction of salicylic acid with (a) one of NaOH. (b) two equivalents of NaOH, and (c) two equivalents of NaHCO_3.
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