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16. Fludrocortisones (Florinef) a. What type of medication is this? M_ b. Action: Increases _reabsorption in renal tubules an

Rudy Guide for Endocrine Agents hobi to bio 0012 e. PTU increases the action of anticoagulants. What is the patient risk? Wha
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16, Fludrocortisone
a, It is a man-made natural substance, also known as glucocorticoids made by the body.
b, action: Increase sodium ions reabsorption in renal tubules and increase urinary excretion of potassium and hydrogen excretion=water and sodium retention.
c, Indications for use
It is a partial replacement therapy for primary and secondary adrenocortical insufficiency in Addison's disease in case of salt-losing adrenogenital syndrome.
d, Combination of Fludrocortisone with glucocorticoid to provide substitution therapy to make adrenal activity normal to reduce the adverse effects.
e, Average and large dose of cortisone can elevate the blood pressure, water and salt retention and high potassium excretion.
f, Adverse effect:
i, headache:
When fludrocortisone used for a prolonged period it increases the  intracranial pressure and causes headache
ii, edema:
Due to mineralocorticoid activity, there will be sodium and water retention it includes hypertension, edema, cardiac enlargement, congestive heart failure, potassium loss, and hypokalemic alkalosis.
g, Patient should be monitored for serum electrolyte determinants because high salt and water retention can cause high potassium excretion
Monitor the patient salt intake, edema, and weight gain
Have dietary salt restriction and potassium supplements
there will be calcium excretion due to high corticosteroids.
h, nursing diagnosis
-Fluid volume retention
-Acute pain
-Electrolyte imbalance
-risk for injury

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