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How would mutations in the GLUT 4 transporter contribute to the pathogenesis of type 2 diabetes?...

How would mutations in the GLUT 4 transporter contribute to the pathogenesis of type 2 diabetes? Is there any research to support this mechanism as a contributor to the progression of this disease?

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Glucose transporter 4(GLUT 4), the predominant insulin responsive glucose transporter isoform, plays a key role in the process of transporting extracelluar glucose in to insulin sensitive cells in vivo.It exist in adipose tissue and skeletal muscle.It is responsible for glucose transportation.This glucose synthesized or decomposed to glycogen to maintain normal glucose tolerance.If GLUT4 in type2 diabetes patients indicates that the patient not able to process glucose.

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