Question

interpret the results of each figure (T2DM - type 2 diabtetes melittus) and how it relates to the hypothesis that Type 2 diabetes melittus is associated with dysregulated gene networks.

. FOR <0.05 (n=31) o FOR 2011 (266) OFDR <0.2 (n=182) oo d Unmatched T2DM Matched T2DM (N=74) e sde Unmatched Control (N=106) B3 -218379388 Matched Control (N=148) 200 -Log10 (pvalue) og 04 0.6 0.2 Propensity Score -0.2 00 02 Logz Fold Change Figure 1 Differential expression analyses reveal a large number of significant T2DM-associated genes in the human skin (A) Jitter plot shows the distribution of propensity scores in the T2DM and control groups. (B) Volcano plot shows the log10 (P-value) and logz fold change for all expressed genes. Differentially expressed genes in the T2DM at the FDR level of 0.05, 0.1, and 0.2 are indicated by red, green and yellow respectively.

Answer 1

Type 2 diabetes mallitus is a metabolic disease associated with risk of substantial disability.

The figure shows the complexities of type 2 diabetes. The common varients in gene influencing pancreatic beta cell function can make a contribution to the inherent component of type 2 diabetes mallitus. The study of gene contribution to positional cloning approach.

It is widely accepted that type 2 diabetes mallitus is a complex disease as an action of genetic background and environmental factors. A number of genes has been identified associated with the same. The genes perform a biological function in a cooperative way but not alone. A signalling pathway of pathological mechanism was more important than individual genes. There are many more number of signalling pathways related to type 2 diabetes mallitus.