Question

write a discussion that explains
1. Insulin and oral drugs for diabetes mellitus
2. HMGcoA reductase inhibitors

Answer 1

1. Insulin and oral drugs for diabetes:

Oral drugs or Oral hypoglycemic agents are suitable for Type 2 Diabetes Mellitus in which body have some capability to produce insulin of its own but not sufficient to meet the needs of body. Oral drugs stimulates the Beta cells of Islets of langerhans in pancreas to produce more insulin.

But insulin more meant for Type 1 Diabetes mellitus in which body cant make any of their own insulin, for them the one and only option is depending on external insulin.Unfortunately insulin dont come in tablet form because by ingesting orally it will get destructed by the gastric acids, So insulin is presently coming in injectable forms only.

A large percentage of people with Type 2 diabetes mellitus ultimately needs insulin.

2.HMGcoA reductase inhibitor:

HMGcoA reductase inhibiitors are commonly known as statins are hypolipidimic agents that work by blocking the enzyme HMG coA reductase that is involved in the synthesis of mevolonate, a naturally occuring substance that is often used by the body to make sterols including cholestrol, thus by inhibiting this cholestrol and LDL production is decreased. In simple these are agents or drugs used to lower the high cholestrol levels.

Commonly used statins are Atorvastatin and Rosuvastatin.