Question

In which condition would amylase but not lipase be elevated? Pancreatic cancer Peptic ulcer Macroamylasemia Renal...

In which condition would amylase but not lipase be elevated?

Pancreatic cancer

Peptic ulcer

Macroamylasemia

Renal failure

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Answer #1

ANSWER IS OPTION C - MACROAMYLASEMIA

Macroamylasemia is the presence of an abnormal substance called macroamylase in the blood.

Causes

Macroamylase is a substance that consists of an enzyme, called amylase, attached to a protein. Because it is large, macroamylase is filtered very slowly from the blood by the kidneys.

  the condition has been associated with:

  • Celiac disease
  • Lymphoma
  • HIV infection
  • Monoclonal gammopathy
  • Rheumatoid arthritis
  • Ulcerative colitis

in pacreatic cancer both the srum amylase and serum lipase level is elevated, because these enzymes are produced by the pancreas,malignancy causes increased proliferation and high level of enzymes.

In peptic ulcer both the amylase and lipase are elevated ,mainly in perforated peptic ulcer.

In renal failure both the amylase and lipase are elevated because the renal insufficiency causes decreased clearance of the enzyme.

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