Question

All of the following questions are in relation to the following journal article which is available on Moodle: Parr CL, Magnus MC, Karlstad O, Holvik K, Lund-Blix NA, Jaugen M, et al. Vitamin A and D intake in pregnancy, infant supplementation and asthma development: the Norwegian Mother and Child Cohort. Am J Clin Nutr 2018:107:789-798 QUESTIONS: 1. State one hypothesis the author's proposed in the manuscript. 2. There is previous research that shows that adequate Vitamin A intake is required in early lung development. Babies' lungs begin to develop during the 2nd trimester of pregnancy (26 weeks). Draw a timeline that includes both the induction time and the latent period for childhood asthma (main exposure) at 7 years and maternal intake of vitamin A (main exposure). Looking back at table 3, is there any evidence that Vitamin A intake during pregnancy protects children from getting asthma? Use one statistic from the table to support your answer Draw the causal model proposed by the authors of this study in table 3. Using the data from Table 5, create a two by two table to calculate the relative risk comparing risk of asthma for children at 7 years old between infants that that had cod liver oil supplements daily during their first 6 months of life and those that had no cod liver oil supplementation. 3. 4. 5. Calculate the risk of asthma among the children who had cod liver oil supplements daily Calculate the risk of asthma among the children who did not have the cod liver oil supplements. Use the risk estimates in 5a and 5b to calculate the relative risk. (Note: the relative risk you calculate should be the same as the Crude RR for daily cod liver oil supplements in table 5). a. b. c. d. State, n one sentence, the meaning of the relative risk that you calculated in 5c. 6. Discuss how Bradford Hill's causal criteria for temporarily is met or not met in relation to this study

Answer 1

Answer 1 : Hypothesis :H1 : There will be significant association between child asthma and maternal intake of Vitamin A and Vitamin D

Answer 2 : Answer 3 : Second Quintile (Q2) of total Vitamin A (780-1102 RAEs/d) intake have observered lower prevelence of Asthma

SECONDARY PREVENTION PRIMARY 4ーPREVENTION-A>← PERIOD LATENT Years weeks o f Pregmey EXPOSURE DISEASE MANICESTATION INDUCTION PERIOP TERTIARY PREVENION ExPOUREDISEASE 2 ATION