Question

A 60-year-old man notes that his resting heart rate has been 50-60 beats per minute after he started taking an new drug compared to 70-80 bpm previously. Which of the following drugs would likely lower his heart rate? What is the mechanism of each drug you select? a) metoprolol b) lisinopril c) verapamil d) digoxin e) furosemide MESSAGE * Subject

Answer 1

Answer :

Above following all drugs will have ability to lower the heart rate .

Metoprolol :

• Metoprolol works by slowing the heart rate and relaxing blood vessels ,there by allowing For smoother blood flow and decreased blood pressure .
• Mechanism of action : a beta _1 blocker is a medication that blocks the beta -1 receptors in the body .this kind of receptor is found in heart .it is stimulated bt biochemical action called epinephrine

Lisinopril : lisinopril relaxes and widen the blood vessel .this lower the heart rate and blood pressure .

Mechanism of action : lisinopril inhibits the angiotensin converting enzyme in human and decreases the heart rate .

It is used in heart failure in adults

Verapamil :

Verapamil is also used to control heart rate such as atrial fibrillation .it helps to lower the heart rate ,helping the people to feel more comfortable and increase ability to exercise.

Mechanism of action : verapamil mechanism is to block the voltage dependent calcium channels .

Calcium channels are especially concentrated in the sinoatrial and atrio ventricular nodes ,these can be used to decrease impulse conduction.

Digoxin : digoxin helps by slowing doen and controlling the heart rate.

Digoxin used to treatment atrial fibrillation

Digoxin should be used carefully and in as low a dose as possible .

Mechanism of action : digoxin inhibots the Na-k+ ATP ase membrane pump ,resulting in increasing in intracellular sodium concentration ,enhancing sodium calcium exchange and producing higher intracellular calcium concentration .

Furosemide : lasix is the brand name of furosemide .

It is used to eliminate extra water and salt in people who have problems with fluid retention and it decreases the blood pressure and heart rate .

Mechanism of action : furosemide is a loop diuretic inhibits water reabsorption in the nephron by blocking the sodium potassium -chloride cotraspirter in the thick ascending limb of the loop of henle .