Question

Anatomy ano phy srotogy and a mology of (citabole bowe Syndlrome ( 85)?

Answer 1

# Irritable bowel syndrome is a functional bowel disease characterized by chronic abdominal pain and altered bowel habits in absence of any organic cause . It affects the large intestine mostly the colon . It is of three types :-

- IBS -D ( Diarrhoea predominant)

- IBS -C(Constipation predominant )

- IBS -M (Mixed )

# Pathophysiology of IBS is not completely understood . Dysregulation in Brain -GI tract possibly results in :-

- abnormal GI motility

- visceral hypersensitivity

- CNS involvement

- autonomic response

- immune function

# The receptors which play a role in the pathophysiology :-

1. 5HT1P: Activation of intrinsic primary afferent neurons in enteric nervous system

2. 5HT3: Activation of dorsal root or crainial nerve afferent neurons --> Stimulate peristaltic activity

3. 5HT4: Stimulates release of acetylcholine and calcitonin --> Increase GI secretions and motility