Homework Answers
Ordered dose of Drug A is 200mg /day
Average steady state concentration (Cp ) is 1mg / L
What is the average amount (mg ) in the body at steady state ?
Half life of Drug A - 12hours
Volume of distribution - 130L
Bioavailability - 0.9
At steady state , rate of drug administration = rate of drug elemination
Vd = AMOUNT of drug in the body /concentration in plasma (Cp)
130L = amount of drug in the body ÷1 mg/L
Amount of drug in the body = 130L × 1 mg/L
= 130 mg of drug will be present at steady state .
Add Answer to:
QUESTION 8 The administration of a 200 mg/day tablet of drug A (t1/2-12 hours; V 130L;...
drug a (t1/2= 18 hours, v= 80l fe= 0.2 fu= 0.1) is administered as multiple 200...
drug a (t1/2= 18 hours, v= 80l fe= 0.2 fu= 0.1) is administered as multiple 200 mg iv bolus every 12 hours. predict max concentration at steady state.
Drug-A (t1/2° 1 5 hours; V-62 L; fu = 0.1; fe = 0.3) is administered twice...
Drug-A (t1/2° 1 5 hours; V-62 L; fu = 0.1; fe = 0.3) is administered twice a day for 2 weeks. Calculate the accumulation factor at steady state.
QUESTION 4 In one patient drug-A (t1/2° 10 hours; v-55L; fu-0.1 ; fe # 0.4; F-09)...
QUESTION 4 In one patient drug-A (t1/2° 10 hours; v-55L; fu-0.1 ; fe # 0.4; F-09) is administered as two 300 mg day. In another patient, the same drug is administered as one 200 mg tablet three time a day. The two dosing regimen have the same dosing rate. O True tablets once a e False
QUESTION 12 Typical PK parameters for drug Drug-D are: F-0.01; fexs 0.4; fua 0.2; V 1.5...
QUESTION 12 Typical PK parameters for drug Drug-D are: F-0.01; fexs 0.4; fua 0.2; V 1.5 L/kg; half-life-3 hours. Calculate the amount in (mg) of drug in the body of a 220 pound patient at steady state when the drug is infused at 60mg/hour.
Typical pharmacokinetic parameters of DRUG-A are F-0.02; fex < 0.1; fu 0.3; V- 0.22 L/Kg Half-life...
Typical pharmacokinetic parameters of DRUG-A are F-0.02; fex < 0.1; fu 0.3; V- 0.22 L/Kg Half-life 4 hours. Drug-A is administered as a continuous IV-Infusion to a patient taking another medication that is known to induce the hepatic-metabolism of Drug-A. Therefore, the time to reach steady state will: D Increase 0 Decrease O Show little difference
can anyone help me solve this pharmokientics question Part 1 of 2 12. A steady-state plasma...
can anyone help me solve this pharmokientics question
Part 1 of 2 12. A steady-state plasma concentration of 25 mg/L v by IV infusion to healthy volunteers (average weight, 75 kg) at a rate of 7.5 mg/kg/hr for 6 hours. Calculate the total body clearance of this drug. A. 12.5 L/hr B. 22.5 L/hr C. 42.5 L/hr D. 62.5 L/hr was measured when a drug was given Part 2 of 2 13. (A steady-state plasma concentration of 25 mg/L by...
7. Smokers are known to have about 50% higher CL than nonsmokers for theophylline. If the...
7. Smokers are known to have about 50% higher CL than nonsmokers for theophylline. If the average observed AUC after administration of 300 mg IV theophylline in nonsmokers is 100 mg.hr/L, what is the expected AUC in smokers after administration of the same 300 mg dose? Theophylline undergoes linear pharmacokinetics 2. After administration of a single 400 mg dose of a drug, a linear plot of the serum concentration-time prorile on a semi-log graph paper showed a y-intercept of 1mg/mL...
14. Gentamicin is often given in IV-bolus doses of 100 mg every 8 hours to achieve...
14. Gentamicin is often given in IV-bolus doses of 100 mg every 8 hours to achieve an average steady-state plasmatic concentration of 5 mg/L. The total clearance is normally 5.4 L/h in a 70 Kg-body weight person. Gentamicin is entirely eliminated by glomerular filtration. Your patient, however, is found to have a creatinine clearance one-third of normal. Your initial dosage regimen for this patient would probably be: a. 20 mg every 8 hours b. 33 mg every 8 hours c....
1. RM (65 kg) is a 78 years old-man with a heart condition. He is hospitalized...
1. RM (65 kg) is a 78 years old-man with a heart condition. He is hospitalized and administered DRUG-A (F 0.02; fe 0.03; t24 hours; Vd 1.2 L/kg) as an iv-infusion. The effective plasma concentration for Drug A is 3 ug/mL a. Calculate the infusion rate necessary to maintain a steady state plasma concentration of 3 ug/mL. b Calculate how long it will take to reach 90% of steady state c. Calculate the loading dose. 2. After three days of...
YOU ONLY NEED TO ANSWER QUESTIONS 1,5, & 8 AND…in addition to answering each question, state 2 other questions aft...
YOU ONLY NEED TO ANSWER QUESTIONS 1,5, & 8
AND…in addition to answering each question, state 2 other
questions after each of these that might be asked of you by a
health professional that would call on you to do the same
calculation, or know the same concept. Give answer for these, and
show all work.
174 Chapter LEARNING QUESTIONS (1) Gentamicin has an average elimination half- life of approximately 2 hours and an apparent volume of distribution of 20%...
Drug-A (t1/2° 1 5 hours; V-62 L; fu = 0.1; fe = 0.3) is administered twice a day for 2 weeks. Calculate the accumulation factor at steady state.
QUESTION 4 In one patient drug-A (t1/2° 10 hours; v-55L; fu-0.1 ; fe # 0.4; F-09) is administered as two 300 mg day. In another patient, the same drug is administered as one 200 mg tablet three time a day. The two dosing regimen have the same dosing rate. O True tablets once a e False
QUESTION 12 Typical PK parameters for drug Drug-D are: F-0.01; fexs 0.4; fua 0.2; V 1.5 L/kg; half-life-3 hours. Calculate the amount in (mg) of drug in the body of a 220 pound patient at steady state when the drug is infused at 60mg/hour.
Typical pharmacokinetic parameters of DRUG-A are F-0.02; fex < 0.1; fu 0.3; V- 0.22 L/Kg Half-life 4 hours. Drug-A is administered as a continuous IV-Infusion to a patient taking another medication that is known to induce the hepatic-metabolism of Drug-A. Therefore, the time to reach steady state will: D Increase 0 Decrease O Show little difference
can anyone help me solve this pharmokientics question
Part 1 of 2 12. A steady-state plasma concentration of 25 mg/L v by IV infusion to healthy volunteers (average weight, 75 kg) at a rate of 7.5 mg/kg/hr for 6 hours. Calculate the total body clearance of this drug. A. 12.5 L/hr B. 22.5 L/hr C. 42.5 L/hr D. 62.5 L/hr was measured when a drug was given Part 2 of 2 13. (A steady-state plasma concentration of 25 mg/L by...
7. Smokers are known to have about 50% higher CL than nonsmokers for theophylline. If the average observed AUC after administration of 300 mg IV theophylline in nonsmokers is 100 mg.hr/L, what is the expected AUC in smokers after administration of the same 300 mg dose? Theophylline undergoes linear pharmacokinetics 2. After administration of a single 400 mg dose of a drug, a linear plot of the serum concentration-time prorile on a semi-log graph paper showed a y-intercept of 1mg/mL...
14. Gentamicin is often given in IV-bolus doses of 100 mg every 8 hours to achieve an average steady-state plasmatic concentration of 5 mg/L. The total clearance is normally 5.4 L/h in a 70 Kg-body weight person. Gentamicin is entirely eliminated by glomerular filtration. Your patient, however, is found to have a creatinine clearance one-third of normal. Your initial dosage regimen for this patient would probably be: a. 20 mg every 8 hours b. 33 mg every 8 hours c....
1. RM (65 kg) is a 78 years old-man with a heart condition. He is hospitalized and administered DRUG-A (F 0.02; fe 0.03; t24 hours; Vd 1.2 L/kg) as an iv-infusion. The effective plasma concentration for Drug A is 3 ug/mL a. Calculate the infusion rate necessary to maintain a steady state plasma concentration of 3 ug/mL. b Calculate how long it will take to reach 90% of steady state c. Calculate the loading dose. 2. After three days of...
YOU ONLY NEED TO ANSWER QUESTIONS 1,5, & 8
AND…in addition to answering each question, state 2 other
questions after each of these that might be asked of you by a
health professional that would call on you to do the same
calculation, or know the same concept. Give answer for these, and
show all work.
174 Chapter LEARNING QUESTIONS (1) Gentamicin has an average elimination half- life of approximately 2 hours and an apparent volume of distribution of 20%...
Most questions answered within 3 hours.
-
Where is the error in this code sequence?
String s1 = "Hello";
String s2 = "ello";...
asked 11 months ago -
Financial data for Joel de Paris, Inc., for last year
follow:
Joel de Paris, Inc.
Balance...
asked 11 months ago -
Consider this reaction:
Al2(SO4)3 (aq)+ BaCl3
(aq) Al2Cl6 (aq)- +
3BaSO4(s) . What is the...
asked 11 months ago -
Suppose that Savneet is considering increasing her
recent random sample from 20 car rentals to 40...
asked 11 months ago -
Trucks arrive at an unloading terminal at an average rate of 120
per hour.
Trucks arrive...
asked 11 months ago -
Why are methanol and ethanol completely soluble in water while
octanol is not very little soluble....
asked 11 months ago -
A facilities manager at a university reads in a research report
that the mean amount of...
asked 11 months ago -
When the CuSO4 is rehydrated by adding water to the anhydrous
compound, is this an endothermic...
asked 11 months ago -
A ray of sunlight is passing from diamond into crown glass; the
angle of incidence is...
asked 11 months ago -
A block of mass 0.249 kg is placed on top of a light, vertical
spring of...
asked 11 months ago -
how do the kidneys compensate in the presences of acidosis
a) trigger hyperventilate
b) reserve acid...
asked 11 months ago -
Question 501 pts
The rental rate of capital to the firm increases. Which of the
following...
asked 11 months ago