A patient is administered a drug through IV infusion at a rate of 300 mg/h. The...
A patient is administered a drug through IV infusion at a rate of 300 mg/h. The drug is eliminated from the body via urine and the halflife is reported as 5h. Based on the patient’s weight, you are expecting a steady-state level of 7 mg/ml.
A) Based on these assumptions, how much is Vd?
B) A blood test shows that the concentration of the drug in the plasma is 15 mg/ml. Looking at your assumptions, what might have been wrong?
C) What would you change to address this?
Homework Answers
Infusion rate of the drug = 300mg/hour
Half life = 5hours
Concentration at steady state = 7mg/ml
A. Volume of distribution = Total Dose / Concentration
= 300/ 7
= 42.8 ml
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