Question

can anyone help me solve these pharmokientics questions 1 and 2

mu sog 1 A m sd of bnuot zew o6t ybsete r6 gub to noidsinoonoo smzsi Part 1 of 3 nd A drug is to be administered by continuous IV infusion to a patient. The drug has a ke of 0.1 h-1 hours and a volume of distribution of 20 L. The desired therapeutic plasma concentration of the drug is 10 mg/L Calculate an appropriate loading dose.gm S o t6 usset n A. 200 mg B. 250 mg o uinesiq erls snid oT gm 02 eo vbss 1. 9J6 naia ordtsas LOadiNg Dose a CP C. 375 mg seiq D. 500 mgidaildstes 1ot st6u 0 2i nometste gniwollot sds to dbidW nofutl to oto0 au10 guid 8 unty A ud osnemereni noltstnaonoo gunb a Part 2 of 3 .ca (d) TO 0.01 0.2.0.1 0.O () s-sH 08,21 0,01 (gm) (A drug is to be administered by continuous IV infusion to a patient. The drug has a ke of 0.1 h-1 hours and a volume of distribution of 20 L. The desired therapeutic plasma concentration of the drug is 10 mg/L).n Calculate an appropriate infusion rate.d o bajupon ton al sanbanibeo A. 20 mg/hr B. 50 mg/hr C. 75 mg/hr Bud aD. 100 mg/hr 2. t bsviupan Jon 2ioeob anibsa8 emit ot eisuA 2oM el tnsmelete gaiwolol adz to rai

Answer 1

1. Answer

The volume of distribution = 20 liter

Plasma concentration = 10 mg/liter

Loading Dose = AMOUNT OF DRUG IN THE BODY / BIOAVAILABILITY (F) X SALT FRACTION (S)

Amount of Drug within the body ( target concentration or the plasma concentration. X volume of distribution.

LOADING DOSE= C X Vd

   LOADING DOSE = 10 mg / liter X 20 litre.

= 200 mg

option (A) 200 mg is the right answer.

Answer 2.

The volume of distribution (VD) = 20 liter

Plasma concentration ( CSS) = 10 mg/liter

kR= o.1hr-1hr = 0.1

Infusion rate =?

Infusion rate (R) = Css X Vd X kR

= 10 mg / litre X 20 litre X 0.1 hour

= 20 mg / hour

option( A) Is the right answer.