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If Ms. Harris has a known allergy to Penicillin, would it be reasonable to treat her...

If Ms. Harris has a known allergy to Penicillin, would it be reasonable to treat her acute sinusitis with Cephalexin and why ? What type of allergic reaction to Penicillin would be an absolute contraindication to prescribing Cephalexin ?

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Answer #1

Cephalosporin belongs to first generation antibiotic, it can used safely in patients allergic to penicillin with hardly 10% of reactions .So a complete allergic history and the effects has to be monitored closely in these patients.

If a patient has developed anaphylaxis as a allergic reaction to penicillin, then the cephalosporin is strictly contraindicated because it can cause an effect similar to penicillin and cause anaphylaxis of hypersensitivity to the drug leading to fatal events.

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