Question

Anti-Fungals Azole - Fluconazole/Ketoconazole Others Amphotericin B, Nystatin

Answer 1

PAGE NO.: | DATE: - Anti-fungal drugs are drugs which are used for Superficial and deep fungal infections. Ketoconazole is a broad spectrum antifungal agent À M.O.A. A inhibit the enzymes - that are used in the formation of ergosterol * Pharmacokinetics n is absorbed in Gastro-intestinal tract. It's absorption is good in Stomach's acidic environment. A dose oraly 200 mg ☆ side effects Nausia - Vomiting - Anoreria y dark Colored wrine Hepatotoxicity rashes and fever use ketaconazole is a broad Spectrum antifungal agent which can be used for ringworm infection athlet's fort etc!

Amphotericin-B It is a fungicidal agent Streptomycese nodusus & obtained from M.o.A 7 Bind with ergosterole and create micropores in fungal Cell that cause lickage of intracellular Ions & enjymes & almastly the fungal Cell 1 is dead. Pharmacokineticstion n is not absorbed. Can w e be given odaly for intestinal Candidiasis without Systemic toxicity. administer IV. as Suspension. s

the body but It get widely Penetration in distributed in CSF is poor. in liver. - Pot is 15 days. about 60% of AMB is metabolised excretion occurs slowly both bile. in wrine & dose 50-100 mg OID adverse effect Anaemia C due to reduced - Production by tubular Coll) 1) erythropoitic damaged renal 2) renal damage u muscle spasm, Vemitting, headach hypertension 5). Azatemia drug interaction > h Coc administration with other nephron toxic drugs i se renal damage. AMB e flucytosine Produced the Synorgistic effect on a nothinh

use . It is drug. a broad spectrum antifungal Can be Candidiasis used s and Cutaneous for oral, vaginal otomycosis. lichmaniasis.