Question

1,How is the concept of perfusion related to each patient

2,Why does studying the concept of perfusion a better learning experience than studying a disease process independently, for instance, stroke.

Answer 1

Ans) 1) Central perfusion is generated by cardiac output—the amount of blood pumped by the heart each minute. Significant reduction of central perfusion results in shock, which occurs when blood supply to tissues is impaired because of inad- equate cardiac output, significant blood loss, or vasodilation throughout the body.

2) Stroke is a heterogeneous syndrome caused by multiple disease mechanisms, but all result in a disruption of cerebral blood flow with subsequent tissue damage.

- The mechanisms responsible for regulation of the normal cerebral circulation, and how they are disrupted in disease states.

- A central concept in treating patients with acute ischaemic stroke is the existence of an ischaemic penumbra of potentially salvageable tissue, and the evidence for its existence in humans is reviewed.