Question

please show me the formula ang how to calculate thank u

3. The prescriber orders 500 mg amoxicillin IVPB q8 hr for a patient with an infection. The recommended safe and therapeutic dosage of amoxicillin is 20-40 mg/kg/day divided in equal doses q8 hr. The patient's current weight is 75 pounds. The 500 mg of amoxicillin is contained in a 100 mL bag of normal saline and is to be infused over 1.5 hours. Calculate the safe "single dose range" for each 8 hour dose (mg/dose). Round to the nearest tenth or hundred th if needed.

Answer 1

1. The dose should be calculated in Kilogram so, we have to converted pound to kilogram

1 pound = 0.454 kg

75 pound ( $75\times 0.454= 34.05$ kg) Let's consider it 34 kg

2. Then the daily therapeutic dose should be 20-40 mg/kg/day

$20mg\times 34kg= 680mg$/1day to $40mg\times 34kg= 1360mg$ /1day

So, a therapeutic dose should range from 680mg to 1360 mg per day

3. We have to give medication equally in an interval of 8 hr

$680\div 3= 226.66$mg (230 mg) to $1360\div 3= 453.33$ mg (450mg)

    Ans. So, the dose should be 230 mg to 450 mg 8hrly

4. Ifusion rate

500mg in 100 ml of NS

Then we have to infuse 230 ml to 450ml in 8 hrly