Question

2. Fill in the squares with the correct configuration (R or S) for the following compounds and determine whether they are Enantiomers, Diastereomers, the Same Compound or Constitutional Isomers. (4 pts) A) Enantiomers B) Diastereomers 11111 Br 011111 Br C) Same Compound D) Constitutional Isomers ОН

Answer 1

Solution=

According to CIP rule

1. When there is isotopes, the atom with the higher atomic mass receives higher priority.

(2) When visualizing the molecule, the lowest priority substituent should always point away from the viewer (a dashed line indicates this).

(3) Then, draw an arrow from the highest priority atom to the 2nd highest priority atom to the 3rd highest priority atom. Because the 4th highest priority atom is placed in the back, the arrow should appear like it is going across the face of a clock. If it is rotates clockwise, then it is an R-enantiomer; If it is rotates counterclockwise, it is an S-enantiomer.

(4) when the lowest priority atom towards the viewer, then the clockwise rotation gives S- enantiomer and the anticlockwise rotation gives R- enantiomer.

0 1 OH (R)-2-[(2R,5R)-5-bromotetrahydro-2H-pyran-2-yl)butan-2-ol 30- (R)-2-(2R,5R)-5-bromotetrahydro-2H-pyran-2-yl)butan-2-ol

since both the compound has same stereochemistry on the chiral center i.e. R. So both are same compound.