Question

500 students entering X University in 2000 had their blood cholesterol levels measured.Screening tests A and B were used to detect abnormal cholesterol levels defined as 200 mg/dl or higher.The sensitivity of test A is 80% and the sensitivity of test B is 90%.The specificity of test A is 70% and the specificity of test B is 80%. Review of medical records

reveals that 40% of the class has abnormal cholesterol levels.

(3)Which of the following testing methods will correctly classify the most students with abnormal cholesterol levels?
a.Test A by itself
b.Test B by itself
c.Test B used to confirm abnormal levels detected by test A(sequential testing)
d.Test A used to confirm abnormal levels detected by test B(sequential testing)
e.Simultaneous testing with A and B to detect any abnormal levels

Answer 1

Test B sensitivity and specificity both are higher than Test A and its PPV and NPV are also higher than the test A, so in conclusion, only Test B by itself is sufficient to test cholesterol level.

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