13. Complete the following reactions from Chapter 22. Show stereochemistry when relevant pts) NH2 NaBH3CN 1....
Practice Problem 22.68b Starting with benzene, show how you would prepare the following compound: NH2 NH2 cl 1) HNO3, H2SO4 2)? Compound A Cla 3)? 4) ? 5) H30* Choose from the following list of reagents: A B с D Fe, H3O+ CuCN LDA H30+ E F G H NaOH, heat NaOEt/EtOH H20 HCI, Zn[Hg), heat J K L CO2 NaNH2, NH3 [H] NaBH3CN NaNO2 HCI
Complete the following reactions with appropriate stereochemistry (18 pts). Circle the appropriate Stereochemistry and Regiochemistry where it is required Br NaOCHA, CH OH O3, H20, Na,SO3 C. NaOET, HOE 1. BH3 , THE CI Heat 2. H2O2, NaOH d.
Provide the major organic product from each of the following reactions. NH2 (1) cat. HA (2) NaBH3CN 2 Br (1NaCN Edit (2) LiAIH (3) H o 2 Br (1)NaNs Edit (2) LiAIH (3) H O 2 Edit (1) NH3, HA (2) NaBH3CN NH2 2 Edit (2) LiAIH (3) H3o
Complete the following reactions KMnO4 / heat NH2 AICI 2/CuCl OH HO 1. CH;CH2Cl/ AlCl 2. KMnO4 3. HNO3/ H2SO4 4. SnCl2/H3o AlCl Br2 /FeBr3 AlCl CI /AlCl 3. KMno
6. (24 pts) Complete the reactions shown below, remember to show all relevant stereochemistry. For products only draw the MAJOR product, if the conditions yield no reaction indicate "no reaction." Alkyl Halide H C Br HỌC CH, NaOCH,CH Br bo o led bono
Using the reagents listed below, propose a synthesis of the target compound starting from benzene. Assume all reactions are appropriately worked up and that mixture of constitutional isomers can be separated. CI NH2 A. Cl/FeCl3 B. HNO3/H2SO4 C. CH3COCI/AICI: D. NaNO2/HCI E. HC1/Cuci F. KCN/CuCN G. H3PO2 H. H2O/heat I. H Cr04 J. 1)LiAlH4 2)H20 K. H/Ni L. 1) Mg 2)CO2 3)H30 M. CH3OH/H30+ N. (CH3)2SO4 NaOH O. CH3OH SOCI Q. HCI R. NaN3
1. Draw the product(s) of the following reactions. Include stereochemistry when relevant. If stereoisomers are formed then draw out and label the relationship between your structures. Ph-N3 40°C HN-NH2 SACOMe 150 °C d. CO2CH3 210 °C нсОСН3 In hv ZI 160 °C OBn 85 °C OBn OBno= o 1 equiv. CI K2CO3 heat PhCH N= H 1. LDA (1 equiv.) P 2. Ph Ph 3. aqueous work-up heat EtOH NaOEt 2. Draw the mechanism for the following transformations. I Н...
Write the products of these reactions
-NH2 1. NaNO2, HCI 2. CuCN 1. N(CH3)3 2. Ag20, H20 3.A 1. LAIHA 2. H20 NaN3 1. LATHA 2. H2O NaCN 1. LIAH 2. H20 Br NaCN H. Ni HNO3 H2SO4 NaOH H20 1. NaNO2 HCI 2. HBF 4 CH3 HNO3 Na Cr207 H2SO4 H2SO4 Sn HCI 1. NaNO2 HCI 2. CuCN
Ochem 2 ch 22
Chemistry 2320 Ch 22 Amines (100 pts) h) HN CH2CI2 i) 1) KOH/DMF H2NNH2 N-H E1OH 2) CI NaN3 LAH THF k) NaCN LAH THF DMSO I) HONO2 H2/Ni CH3OH H2SO m) 1) SOCI2 /pyr LAH THF NH2 2) n) H2/ Ni NH2 CHO+ CH-он o) H* (cat) NABH3CN NH2 -H2O CHОH Page 6 of 8
Give the major organic product(s) of the following reactions or
sequences of reactions. Show the stereochemistry and/or isotope
position clearly where it is relevant. If you think that the
reaction would not occur, write as "NR" or "No Reaction."
A) 1) NaOH ОН ? 2) CH3CH Br B) 1) NH3, excess 2) SOC12, Pyridine, heat CI