Question

please use R and show input and output. Any data that is needed is provided in the question

Question 3: Under certain conditions, animal cell lines can become "immortalized," meaning they will keep growing and dividing indefinitely in laboratory cultures. Nowak et al. (2004) looked at the effect of the pro-apoptotic protein Bax on immortalization of mouse muscle cells. They made mice without the Bax protein (Bax), established cell lines from them, and compared them to cell lines from mice with the Bax protein (Bax and Bax). After 50 days, all 7 lines of Bax cells were still growing, while only 3 out of 9 of the lines with Bax were growing. Use the most appropriate statistical procedure for testing whether the cell line survival rate is different between those cell lines derived from Bax protein to those that are not.

Answer 1

Answer:

R code:

grow <- c(7,3)

total<- c(7,9)

prop.test(grow, total, conf.level = 0.95,correct = FALSE)

R output:

>grow <- c(7,3)

> total<- c(7,9)

> prop.test(grow, total, conf.level = 0.95,correct = FALSE)

        2-sample test for equality of proportions without continuity

        correction

data: grow out of total

X-squared = 7.4667, df = 1, p-value = 0.006285

alternative hypothesis: two.sided

95 percent confidence interval:

0.3586880 0.9746453

sample estimates:

   prop 1    prop 2

1.0000000 0.3333333

Calculated chi square = 7.4667, P=0.0063 which is < 0.05 level of significance.

Ho is rejected.

We conclude that cell line survival rate is different between those two cell lines.