Question

please answer question 9

8 (3 pts.) In the section Designing the Drug Thalidomide", you learned that researchers create various analogs to determine which structural features are necessary for biological activity and which are responsible for side effects. The analogs were created using the molecule shown below. Using the information found in Table 3. draw the corresponding analogs #78, and 11 o N IHz NH2 IC 50.= 150 km Analog #7 "NH2 'NH2 OCHS KTOCH2CH3 "OCH₂ CH3 IC 5o = 120 MM Analog #8 ICso = 5.6mm Analog #11 9. (2 pts) Thalidomide is known to be an inhibitor of TNF-a. TNF-a is a protein mediator, and when too much of this mediator is present, it can cause muscle weakness and body wasting as you read in the section Designing the Drug Thalidomide" and in the background. In Table 3, the concentration at which 50% inhibition of TNF-a production occurs in blood cells (ICso in uM) is provided. Compare and/or contrast the ICso values of thalidomide compared to the analogs that just have the addition of the aromatic ring (compound #6) or the analogs that contain nitrile (-CN; #7) or alkoxy (-OCH, or-OCH2CH3; #8-11) substituents on the added aromatic ring.