Homework Answers
The order says vincristine 25mcg/kg/day.
Since the dose is to be given daily, daily dose = 25mcg/kg/day = (25/1) mcg/kg = 25 mcg/kg.
The patient weighs 95 kg.
Daily dose = 25mcg/kg = (25*95) mcg = 2375 mcg.
Hence the patient should be given 2375 microgram vincristine daily.
Vincristine is a vinca alkaloid anticancer drug. It is a mitotic inhibitor, binds to microtubular protein tubulin, prevents its polymerization and assembly of microtubules, causes disruption of mitotic spindle and interfere with cytoskeletal function. The chromosomes fail to move apart during mitosis: metaphase arrest occurs. It is cell cycle specific and act in the mitotic phase. It is used in cancers like acute lymphoblastic leukemia, wilms tumour, acute myeloid leukemia, Hodgkins disease, Ewing sarcoma, neuroblastoma and lung carcinoma. It's also known as oncovin.
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