Question

Select all of the reagent(s) that will produce octan-2-one as the major product. You must select at least one step 1 reagent and one step 2 reagent, but you should select all correct answers.

Select all of the reagent(s) that will produce octan-2-one as the major product. You must select at least one step 1 reagent and one step 2 reagent, but you should select all correct answers Step 1 reagents CHs Step 2 reagents but-3-en-2-one octan-2-one □ NH4Cl □ H2O NaBH4

Answer 1

Organolithium cuprates, RCuLi are particularlyuseful for conjugate 1,4-additions to alpha, beta-unsaturated aldehydes and ketones. ње сн H2 H2 H2 H2 Нас H2 H2 H2 H2 Step 1: The nucleophilic Carbon in the cuprate attacks the conjugated ketone at the electrophilic alkene Carbon in a nucleophilic addition type process with the electrons being pushed through to the electronegative Oxygen, giving an intermediate enolate. Step 2: On acidic work-up, the enolate is protonated at the o-C creating the more favorable carbonyi group