Question

CH OH HO 100% Me CO-Et HB 2 H-O EtOH AcOH 68% Br T8 Me 77% CH 0H 2 10% HCI in MeCN 1) TsCllpy 2) Nal LDA H (cat.) Me Me 75% CH-OH CH2 Me (8 6 Draw wedge/dash drawing of the following Fischer projection scheme 1-8 and assign the stereocenter(s) R or S absolute configuration

Answer 1

Eto но, Eto Eto Co2Et Co2Et Co2Et H Me (2S,3R)-diethyl 2-hy droxy-3-methylsuccinate (2R,3R)-diethyl 2-bromo-3-hydroxysuccinate (2S,3S)-diethyl 2,3- dihydroxysuccinate 4 HOH CH20H H Me (2S,3S)-3-methylbutane-1,2,4-triol нон но IH H Me (S)-2-((S)-2,2-dimethyl-1,3- dioxolan-4-yl)propan-1-ol H Me (S)-4-((R)-1-iodopropan-2-yl)- 2,2-dimethyl-1,3-dioxolane но Me H Me (1S,2S,4S,5R)-5-ethyl-2,4 dimethyl-6,8-dioxabicyclo[3.2.1]octane (6S)-6-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-4 methylheptan-3-one