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1. Why can we use methyl alcohol to dissolve an aspirin tablet? 2. When Phenolphthalein is...

1. Why can we use methyl alcohol to dissolve an aspirin tablet?

2. When Phenolphthalein is added in a solution, the solution turns to pink but clears up when swirled. why/how did the solution became clear?

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Answer #1
  1. In chemistry there is a concept of like dissolve like that means polar compound will get dissolve in polar solvent. Similarly non-polar will get dissolve in non-polar solvent. Aspirin contains a benzene ring (non polar), a carboxyl group (polar), and an ester. Hence it has both polar and non-polar components.

Methyl alcohol (CH3OH) contains a methyl group and hydroxyl group. It is highly polar compound, so its affinity for aspirin is very low and solubility will be less.

Moreover methyl alcohol is toxic to living beings, hence traces of this solvent left can harm. Hence it is mostly avoided in pharmaceutical usage.

Ethyl alcohol is slightly non polar (CH3CH2OH) as compare to methyl alcohol and safer to use. Its polarity matches that of aspirin due to additional carbon group, hence it also has both polar and non-polar component. Hence aspirin tablet will get dissolve in this.

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